描述
E.Coli Recombinant
BETAGENE Human Fms-related Tyrosine Kinase 3 Ligand



ProductCatalog No.
SpecificationShelf lifePrice

BETAGENE rhIL-2

GE05.1

100μg

24 months450

GE05.1

200μg600


ProductCAT. No.
VolumnShelf lifePrice

rhIL-2

GE05.1

100μg

24 months450

GE05.2

200μg600
描述
产品描述
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IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.


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储存分类代码

WGK闪点(F)

13 - Non Combustible Solids

WGK 3

Not Applicable

闪点(C)

个人防护装备

Not Applicable

dust mask type N95 (US), Eyeshields, Gloves

  • Specs

  • Data

Appearence

Sterile Filtered White lyophilized (freeze-dried) powder.

Gene ID

2323

AA Sequence

TQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPTA
Host E.Coli

Molecule Weight

Approximately 17.6kDa, a single non-glycosylated polypeptide chain containing155 amino acids.

Biological Activity

The ED50 as determined by a cell proliferation assay using human AML5 cells is <1.0 ng/mL, corresponding to a specific activity of ≥1.0 × 106 Units/mg.
Purity >98% by SDS-PAGE or HPLC
Formulation Lyophilized from a 0.2 µm filtered concentrated solution in 20mM PB, 150mM NaCl, pH7.4
Host Cell DNA< 0.02 ng/μg of protein
Host Cell Protein
< 0.05% when tested by ELISA
Mycoplasma Negative

Endotoxin (LAL)

< 0.01 EU/μg
Sterility Negative

Reconstitution

Before use this product, please read the direction below carefully.

1.    This vial must be briefly centrifuged prior to opening to bring the contents to the bottom.

2.    Reconstitute in a sterile aqueous buffer to an appropriate concentration.

3.    Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stability&Storage

For long term storage, the product should be stored ≤-20°C.

Please avoid repeated freeze-thaw cycles after reconstitution.

1. 12 months from date of receipt, -20 to -70 °C as supplied.

2. 1 month, 2 to 8 °C under sterile conditions after reconstitution.

3. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended in our USER MANUAL.



Description

Fms-related Tyrosine Kinase 3 Ligand (Flt3L) is a growth factor that regulates proliferation of early hematopoietic cells. Flt3L binds to cells expressing the tyrosine kinase receptor Flt3. Flt3L, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3L exerts no activity on mast cells. Multiple isoforms of Flt3L have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein. The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform.

Data


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Technical Data
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SDS
User Manual
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